Clinical Trials Logo

Clinical Trial Summary

The primary objective of this study is to assess the rate of engraftment with combined haploidentical-cord blood transplantation in patients with pre-existing donor specific antibodies and in those with active disease.


Clinical Trial Description

Primary Objective

- To assess the rate of engraftment with combined haploidentical-cord blood transplantation in patients with pre-existing donor specific anti-HLA antibodies and in those with active disease

Secondary Objectives

- To determine the long term fate of the haplo transplant and the cord blood transplant in this setting.

- To describe the incidence and severity of acute and chronic GVHD. ;


Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01359254
Study type Interventional
Source University of Chicago
Contact
Status Terminated
Phase Phase 2
Start date April 2010
Completion date June 2012

See also
  Status Clinical Trial Phase
Completed NCT02660281 - URMC Related Haplo-identical Donor BMT Phase 1
Completed NCT03004261 - CMV-CTL for the Treatment of CMV Infection After HSCT Phase 4
Recruiting NCT01684189 - Registry of Febrile Neutropenia and Invasive Fungal Infections N/A
Completed NCT02447237 - Randomized Trial:the Effect of Liquid Food on the Intake of Energy and Protein in Malignant Hematologic Patients N/A
Not yet recruiting NCT06143098 - Some Hematological Profile in Children With Chronic Kidney Disease
Recruiting NCT04976205 - AI Algorithms to Automate the TMI by VMAT Optimization Using WB-CT/MRI and Synthetic WB-CT - The AuToMI Project N/A
Not yet recruiting NCT06050798 - Hematological Disorder in Patients With Angiodysplasia
Active, not recruiting NCT02158858 - A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis Phase 1/Phase 2
Enrolling by invitation NCT02456818 - Assessing the Effect of Contact Isolation on Nosocomial Colonization With ESBL-EC in German Hematology/Oncology Wards N/A
Recruiting NCT05727917 - Hetrombopag for the Enhancement of Platelet Engraftment After Allogeneic Hematopoietic Stem Cell Transplantation N/A
Completed NCT03355742 - XIENCE 28 Global Study N/A
Recruiting NCT00883961 - Exercise Following Autologous Peripheral Blood Stem Cell Transplantation Phase 3
Completed NCT00820508 - Safety and Tolerability of CHR-2845 to Treat Haematological Diseases or Lymphoid Malignancies Phase 1