Molecular Epidemiology of Benzene-exposed Workers.

Hematologic Diseases Clinical Trial

Official title:

Molecular Epidemiology of Benzene-exposed Workers in Shanghai,China

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00364520
• Other study ID #: 02-0037
• Status: Completed
• Phase: N/A
• First received: August 14, 2006
• Last updated: May 19, 2015
• Start date: August 2003
• Est. completion date: December 2009

Study information

• Verified date: May 2007
• Source: University of Colorado, Denver
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review BoardChina: Ministry of Health
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China.

Description:

The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2000
• Est. completion date: December 2009
• Est. primary completion date: December 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 67 Years

Eligibility

Inclusion Criteria:

Worked for at least one year in a monitored environment Have at least one physical examination recorded

Exclusion Criteria:

History of cancer, radiation exposure, chemotherapy

Study Design

Observational Model: Ecologic or Community, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Hematologic Diseases

Intervention

Other:
• Shanghai workers

Locations

Country	Name	City	State
China	Joint Sino-US Clinical and Molecular Laboratory (JCML)	Shanghai

Sponsors (10)

Lead Sponsor	Collaborator
University of Colorado, Denver	British Petroleum P.L.C., Chevron Corporation, ConocoPhillips, Exxon Mobil, ExxonMobil Biomedical Sciences, Inc., Fudan University, Marathon Ashland, Shell Chemicals, University of Cincinnati

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers.	Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers	August 2003 - December 2009	No
Secondary	Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.	Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.	August 2003 - December 2009	No