HELICOBACTER PYLORI INFECTIONS Clinical Trial
Official title:
Gamma-Glutamyl Transpeptidase (GGT): A Potential Diagnostic Marker for Helicobacter Pylori Infections
The investigators hypothesis:
Presence of anti-GGT (antibody against GGT) indicates H. pylori infection.
Subjects will be requested to provide 1-5g of their solid/semi-solid stool sample, to be
collected within 24 hours prior to their scheduled visit for urea breath test. Patients
should not have been treated for H. pylori prior to stool collection. Stool samples will be
tested using ELISA for the presence of the H. pylori GGT antigen using monoclonal antibodies
against GGT. Stool samples will also be tested for the presence of H. pylori DNA using PCR
and Western blot analysis respectively.
Presence of the GGT antigen in stool will be compared between H. pylori-positive and H.
pylori-negative patients. Rapid urease test results will be used as the gold standard of H.
pylori diagnosis. The sensitivity and specificity of the stool antigen test will be
established.
;
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03419936 -
Distribution of Helicobacter Pylori After Gastrectomy
|
N/A | |
| Recruiting |
NCT02047994 -
Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality
|
Phase 4 |