Helicobacter Pylori Infection Clinical Trial
Official title:
The Impact of Antibiotics MIC Value on the Efficacy of Treatment Regimens for Helicobacter Pylori Infection.
Clarithromycin (CLA)、amoxicillin (AMO)、metronidazole (MET)、levofloxacin (LEV) and
tetracycline (TET) are commonly used antibiotics for Helicobacter pylori (Hp) therapy.
However, the efficacy of treatment for Helicobacter pylori infection has decreased due to
increasing resistance to CLA, MET and LEV. Studies had reported that beside antibiotics
resistance, other factors such as age, sex, underlying disease, etc. may also affect the
treatment efficacy. In some cases, when the MIC values were beyond the breakpoint, H. pylori
strains with lower MIC value had better eradication than the ones with higher MIC value.
However, few study investigated the relationship between MIC values and treatment outcome.
The investigators aimed to analyze the impact of influencing factors, especially minimal
inhibitory concentration (MIC) value, on the efficacy of different treatment regimens.
n/a
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