Helicobacter Pylori Infection Clinical Trial
Official title:
A Randomized, Double-blind, Placebo-controlled Study of the Usefulness of the Probiotic 'Lactobacillus Reuteri' in the Therapy of Quadruple Eradication of Helicobacter Pylori Infection in Usual Clinical Practice
Helicobacter pylori is a Gram-negative bacterium with a helical bacillus shape that it's able
to penetrate and colonize the stomach mucosal lining by infecting it.
The eradication treatment of H. pylori is supported by numerous consensus groups worldwide
and it is generally safe and well tolerated. Standard treatment is based on multiple drug
regimens. However, its effectiveness has been increasingly compromised due to the emergence
of resistant strains, as well as poor adherence to treatment. Therefore, it's proposed a
randomized, double-blind, placebo-controlled study whose aims are:
1. Determine whether the combination of two probiotic strains of L reuteri (Gastrus) will
improve gastrointestinal symptoms when associated with four-way therapy (of any type).
2. Prove whether supplementation with Gastrus (food supplement) versus Placebo is able to
reduce the gastrointestinal adverse effects of quadruple eradication therapy.
They will be determined by the GSRS gastrointestinal symptom scale in routine clinical
practice.
n/a
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