Helicobacter Pylori Infection Clinical Trial
Official title:
Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy as Rescue Treatment for Helicobacter Pylori Infection After Failure of Several Therapy
Doxycycline- and Furazolidone-containing Quadruple Regimen can be a successful rescue treatment for Helicobacter pylori Infection patients after Failure of several therapy. It is superior of tailored therapy as rescue treatment for helicobacter pylori Infection after failure of several therapy.
This study is a prospective, multiple centers, randomized trial. Patients who had failed in
previous H. pylori eradication treatment that more than two times will be enrolled in Sir Run
Run Shaw Hospital.
Pretreatment H. pylori status will be defined by a positive 13 C-urea breath test (13 C-UBT).
Patients who had received bismuth compounds, acid inhibitor, or antibiotics during 4 weeks
before 13 C-UBT are excluded. Other exclusion criteria included upper gastrointestinal
surgery, malignancy, and evidence of blood dyscrasia.
After the patient is enrolled the patient will sign the informed consent and receive
gastroscopy. More than four biopsy will be given including two in antrum and two in gastric
body. One pair of biopsy sample will be sent for the pathology and the other pair is used for
H.pylori culture and antibiotics sensitivity. After we get the result of antibiotics
sensitivity the patient will be divided randomly into two groups, Regimen A, Regimen B.
The Regimen A includes esomeprazole (E) 20 mg, doxycycline (D) 100mg, furazolidone (F) 100
mg, and colloidal bismuth subcitrate (B) 100 mg . All drugs are taken twice a day for 14
days. The Regimen B includes two antibiotics based on antibiotic sensitivity of helicobacter
pylori culture, colloidal bismuth subcitrate (B) 100 mg, esomeprazole (E) 20 mg. The
esomeprazole and bismuth are taken half an hour before a meal and antibiotics after the meal.
All patients are asked to quit smoking and drinking and forbid eating foods rich in tyramine
(e.g., chicken, cheese, pickles, lentils, beans) and seafood during and in 1 week after the
treatment.
Patients will be followed up at the 1st day, 14th day, and 4 weeks after the treatment,
respectively, and all side effects will be collected.
;
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