Heart Transplantation Clinical Trial
Official title:
"Detection of Acute Rejection in Heart Transplant Patients by Mean of T2 Quantification With MRI" Open Transversal Clinical Trial With Repeated Measures
The investigators propose a simple and non-invasive method to monitor heart transplant
patients with MRI. Its diagnostic and prognostic values have already been assessed in two
monocentric studies. Other monocentric studies based on related methods have confirmed the
investigators findings. These studies are insufficient to allow a large diffusion of the
technique. Only a large multi-centric study will change medical practices. In addition, this
project will spread the new method at a national level and will allow an assessment of its
practical usefulness in centres not familiar with MRI T2 quantification.
Furthermore, MRI seems to detect rejections at earlier stage than biopsy. A confirmation of
this observation could lead to a modification of diagnostic criteria of cardiac graft
rejection. The ultimate aim of the DRAGET project is to replace a strategy based solely on
biopsy with one based on a first-line MRI (with biopsy only when needed) for a more efficient
and earlier detection of rejection. This would constitute a major advance in patients
security and comfort as well as an economic improvement.
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