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AMBulatory UltraSound for Heart Failure Management — AMBUSH  

Heart Failure Clinical Trial

Official title:
Impact of Ultrasound-guided Therapeutic Management of Ambulatory Patients With Heart Failure : An Open-label Randomized Clinical Trial

Clinical Trial Summary

AMBUSH study is a multicenter randomized, controlled, open-label clinical trial (PROBE (Prospective Randomized Open Blinded End-point) type). The main objective of AMBUSH study is to assess the effect of therapeutic management guided by pulmonary ultrasound and the assessment of the inferior vena cava in patients with heart failure seen in an ambulatory (outpatient) setting on a mixed clinical-biological endpoint (including variations of natriuretic peptides - NtProBNP) at 30 days.

Clinical Trial Description

Secondary objectives are: A. To assess the effect of therapeutic management guided by pulmonary ultrasound and inferior vena cava assessment on the risk of cardiovascular death and hospitalization for heart failure at 30 days. B. Describe the proportion of ultrasound congestion (pulmonary and inferior vena cava data) in patients free from clinical congestion at baseline in the intervention group and in all patients at D30 visit. C. Evaluate the association of ultrasound congestion (pulmonary and inferior vena cava assessment) with serum concentrations of natriuretic peptides at baseline and D30 visit. D. Evaluate the association of variations in ultrasound congestion (pulmonary and evaluation of the inferior vena cava) and variations in natriuretic peptides between baseline and D30 visit. E. Compare the proportion of ultrasound and clinical congestion in patients in the intervention group and in the control group at baseline and on D30 visit. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04741711
Study type Interventional
Source Central Hospital, Nancy, France
Contact Nicolas GIRERD, MD,PhD
Phone +33 3 83 15 74 96
Email n.girerd@chru-nancy.fr
Status Recruiting
Phase N/A
Start date May 15, 2023
Completion date June 15, 2027
View Details
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