Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block) — LEAP-Block  

Heart Failure Clinical Trial

Official title: Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block): A Randomized Controlled Trial

Status Recruiting

Clinical Trial Summary

This is a multicenter, randomized controlled study. The aim of this study is to compare the impact of LBBAP on left ventricular function as compared with traditional right ventricular pacing in patients with atrioventricular block.

Clinical Trial Description

LEAP-BLOCK is a prospective, multi-center, randomized controlled trial that is designed to determine whether left bundle branch area pacing (LBBAP) may reduce the risk of RV ventricular pacing induced cardiac dysfunction as compared with traditional RV pacing (RVP) in patients with atrioventricular (AV) block and normal LV function (LVEF≥50%) who require high percent of ventricular pacing. The primary aim of this trial is to compare the time to first event (composite of all-cause mortality and newly heart failure hospitalization and device upgrade due to heart failure) between LBBAP and RVP group in patients with AV block. Patients with AV block and normal LV function who require high burden of ventricular pacing (expected >40%) will be randomized to LBBAP or RVP group for therapy. Patients will be followed at least every 3 months for clinical status and every 6 months for echocardiographic evaluation until the study closure. ;

Related Conditions & MeSH terms

• Atrioventricular Block
• Heart Failure
• Left Bundle Branch Area Pacing
• Right Ventricular Pacing

• NCT number: NCT04730921
• Study type: Interventional
• Source: Fu Wai Hospital, Beijing, China
• Contact: Xiaofei Li, M.D.
• Phone: +8617801013995
• Email: lixiaofei0103@163.com
• Status: Recruiting
• Phase: N/A
• Start date: November 13, 2020
• Completion date: December 31, 2025