Heart Failure Clinical Trial
Official title:
Changes in the T-wave Alternans in Patients With Heart Failure Treated Wih Sacubitril-Valsartan
The aim of this study is to know if the Sacubitril-Valsartan treatment improves the T-wave alternans in those patients that begin its treatment, which would indirectly show a lower risk of malignant ventricular arrythmias.
Sacubitril-Valsartan has shown to reduce sudden death in its principal clinical trial,
PARADIGM-HF.
A T wave alternans (TWA) is an electrophysiological phenomenon that acts as an independent
predictor of sudden death and ventricular arrhythmias in postinfarct myocardial.
TWA is measured by using a special software and electrodes during a treadmill test, that
analyse small changes in the microvolt of the T wave consecutive with a complex algorithm in
three dimensions. The TWA could be negative (normal), positive (pathological) or
indeterminate. If a TWA is pathological it reflects an electric instability in
depolarization.
Our hypothesis is that the treatment with Sacubitril-Valsartan in heart failure patients with
reduced ejection fraction, could improved the TWA.
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