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Thyroid Hormone Replacement for Subclinical Hypothyroidism and Chronic Heart Failure (ThyroHeart-CHF)

Heart Failure Clinical Trial

Official title:
Efficacy and Safety of Levothyroxine (L-T4) Replacement on Exercise Capability in Chronic Systolic Heart Failure Patients With Subclinical Hypothyroidism: A 24-week, Multi-center, Open Label, Randomized, Parallel Group Trial

Clinical Trial Summary

Based on accumulating evidence showing that hypothyroid status is associated with poor prognosis among heart failure (HF) patients, the study is designed to evaluate whether replacement treatment with levothyroxine could have beneficial effects on patients with HF and subclinical hypothyroidism. The study is a prospective, randomized, parallel-group trial to assess the efficacy and safety of levothyroxine replacement on evidence-based HF standard therapy in stable chronic heart failure patients with subclinical hypothyroidism.

Clinical Trial Description

The primary objective of this trial is to determine whether the 24-week L-T4 replacement therapy, as an adjunct to standard treatment, would improve exercise capability in chronic systolic heart failure patients with subclinical hypothyroidism compared to the standard treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03096613
Study type Interventional
Source Chinese Academy of Medical Sciences, Fuwai Hospital
Contact Xuan Zhang, MD
Phone 00861088396173
Email katiechang@163.com
Status Recruiting
Phase Phase 4
Start date April 18, 2017
Completion date February 2019
View Details
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