Heart Failure Clinical Trial
Official title:
Semaphorins 3A and 4D Levels in Heart Failure Patients: Pathogenesis and Clinical Correlation
This study hypothesis is that Semaphorins 3A and 4D levels are overexpressed in patients
with heart failure. Study protocol:
Hospitallized patients with new onset or previously diagnosed heart failure will be
recruited to the study. Control group will include healthy people with no medical records or
chronic treatment at the same age range. After signing an informed constent form, full
medical history and blood samples will be collected. A second blood sample will be collected
8 weeks later, assuming the patient was discharged and not hospitalized since than. The
blood samples will be analyzed by Bnai Zion Medical Center Immunology labs for the above
semaphorins levels in the heart failure group and control group. Statistical analysis will
then commence for possible correlatoion with different clinical parameters.
Status | Not yet recruiting |
Enrollment | 120 |
Est. completion date | May 2017 |
Est. primary completion date | May 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 50 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Patients with new onset or previously diagnosed heart failure. - Heart failure diagnosis can be based on clinical judgment, echocardiography or elevated BNP levels Exclusion Criteria: - Patients with acute myocardial infarction diagnosed clinicly and labratory |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Bnai Zion Medical Center |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Semaphrone 3A and 4D levels | one year | No | |
Secondary | BNP level | Brain natriuretic peptide level in patient plasma | one year | No |
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