Heart Failure Clinical Trial
Official title:
Semaphorins 3A and 4D Levels in Heart Failure Patients: Pathogenesis and Clinical Correlation
This study hypothesis is that Semaphorins 3A and 4D levels are overexpressed in patients
with heart failure. Study protocol:
Hospitallized patients with new onset or previously diagnosed heart failure will be
recruited to the study. Control group will include healthy people with no medical records or
chronic treatment at the same age range. After signing an informed constent form, full
medical history and blood samples will be collected. A second blood sample will be collected
8 weeks later, assuming the patient was discharged and not hospitalized since than. The
blood samples will be analyzed by Bnai Zion Medical Center Immunology labs for the above
semaphorins levels in the heart failure group and control group. Statistical analysis will
then commence for possible correlatoion with different clinical parameters.
In few previous published studies, Semaphorins 3A levels are overexpressed in patients with heart failure. The aim of our study is the compare semaphorin 3A and 4D in patients with acute decompansated heart failure with healthy donors. Second aim is to compare semaphorin level in the same patients in time of hospitalization and few weeks later when the heart failure presumingly controled. Statistical analysis will then commense for possible correlatoion with different clinical parameters like NYHA (new york heart association) status of the patient, lenghts of hospitalization and BNP (brain natriuretic peptide) levels at time of admition. ;
Observational Model: Case Control, Time Perspective: Prospective
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