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NCT02129179 Clinical Trial

The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure

Heart Failure Clinical Trial

Official title:
The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02129179
Other study ID # PO1860
Secondary ID
Status Completed
Phase Phase 1
First received April 30, 2014
Last updated April 3, 2018
Start date June 2014
Est. completion date December 2016

Study information
Verified date April 2018
Source Papworth Hospital NHS Foundation Trust
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study aims to assess the effect of glucagon-like peptide-1 on cardiac output and transpulmonary gradient in patients undergoing right heart catheterisation for clinical reasons.

Recruitment information / eligibility
Status Completed
Enrollment 10
Est. completion date December 2016
Est. primary completion date December 2016
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Age over 18

- Able to give informed consent

- On the waiting list for heart transplant

- Left Ventricular Dysfunction awaiting catheterisation

Exclusion Criteria:

- Nicorandil, glibenclamide, Dipeptidyl Peptidase-4 inhibitor, Glucagon-Like Peptide-1 receptor agonist or insulin

- Women of child bearing age and breast feeding women

- Cardiac pacemaker or other implanted metallic device

- Unable to give informed consent

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Glucagon-Like Peptide 1

Locations
Country Name City State
United Kingdom Papworth Hospital NHS Foundation Trust Papworth Everard

Sponsors (1)
Lead Sponsor Collaborator
Papworth Hospital NHS Foundation Trust

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change in Pulmonary Vascular Resistance with Glucagon-Like Peptide-1 30 minutes
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