Cardiac MR (CMR) in Cardiac Resynchronization Therapy Non-responders

Heart Failure Clinical Trial

Official title: Cardiac MR (CMR) in Cardiac Resynchronization Therapy (CRT) Non-responders: Therapy Optimization by Means of Tissue Characterization, Hemodynamic Analysis and Analysis of Myocardial Activation

Status Terminated

Clinical Trial Summary

Cardiac MR (CMR) will be used to assess myocardial activation and hemodynamics in patients with CRT.

Goals are to demonstrate that

• differences in Left ventricle (LV)- right ventricle (RV) pacing delays cause differences in myocardial activation

• differences in LV-RV pacing delays cause differences in LV/RV hemodynamics

and to use these data to optimize CRT.

Clinical Trial Description

CMR will be performed in patients under CRT who are currently not responding to CRT. Different LV-RV delays will be programmed during CMR and LV function and different dyssynchrony parameters will be assessed. Results will be used to determine the optimal LV-RV delay, and CRT-devices will be reprogrammed accordingly. Improvement in NYHA-class/conversion to therapy responder will be determined clinically after 3 months. ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Heart Failure

• NCT number: NCT01367691
• Study type: Interventional
• Source: University Hospital, Bonn
• Status: Terminated
• Phase: N/A
• Start date: June 2011
• Completion date: December 2013