Risk Stratification and Benefits With Cardiac Resynchronization Therapy (CRT) — BENEFIT  

Heart Failure Clinical Trial

Official title: Risk Stratification and Benefits With Cardiac Resynchronization Therapy

Status Completed

Clinical Trial Summary

This is an observational study to learn which patients benefit from CRT therapy and to track the clinical changes that help identify the risk-level of CRT patients.

Clinical Trial Description

The purpose of the study is two-fold. First, to determine if an algorithm can be developed based on pre-implant clinical variables to predict response to CRT-D therapy. Second, the study aims to determine in patients implanted with CRT-D if the combined use of cTnT and BNP can further predict and risk-stratify HF improvement and all-cause mortality. Additionally, novel biochemical markers defining cardiac mortality in high risk patients detected by plasma proteomic analysis in the CRT-D patients will be evaluated.

This study represents a combination of previous CRT studies that evaluated these variables independently. Data from this study will be pooled with data from previous studies to build a more complete picture of CRT therapy. ;

Related Conditions & MeSH terms

• Heart Failure
• Ventricular Arrhythmias

• NCT number: NCT00996086
• Study type: Observational
• Source: Abbott Medical Devices
• Status: Completed
• Start date: February 2010
• Completion date: September 2012