Heart Failure Clinical Trial
Official title:
Collaborative Systematic Overview of Randomised Controlled Trials of Beta-Blockers in the Treatment of Heart Failure
Several large trials have shown that beta-blocker treatment reduces the risk of death and
hospital admission in patients with symptomatic heart failure. Unfortunately, survey data
suggests relatively poor utilisation of beta-blockers, despite ample evidence for good
tolerability. Additionally there are several important unanswered questions, such as
clinical efficacy for specific sub-populations (women, the elderly and patients with
diabetes or other co-morbidities) and the effect of beta-blockers in combination with other
medications. Previous meta-analyses, based on published tabular data, have been conducted
although this approach has important biases and limitations.
We plan to perform a carefully conducted systematic review of individual patient data from
the major randomised trials of beta-blockers in heart failure. The goals of this
collaborative project are to clarify the overall efficacy of beta-blockers and identify
sub-groups that show particular benefit, thereby increasing the use of beta-blockers,
reducing adverse clinical outcomes and the high costs associated with this condition.
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