Does Ascorbic Acid Reduce Sympathoexcitation in CHF?

Heart Failure Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00550121
• Other study ID #: CHFVIT
• Status: Completed
• Phase: N/A
• First received: October 25, 2007
• Last updated: October 13, 2008
• Start date: August 2007
• Est. completion date: April 2008

Study information

• Verified date: October 2008
• Source: Radboud University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
• Study type: Interventional

Clinical Trial Summary

In CHF central sympathetic activity is increased. ROS formation seems to play a role in this process. This study analyzes the effect of vitamin C as an antioxidant on central sympathetic activity in CHF

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: April 2008
• Gender: Both
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Heart failure of at least New York Heart Association (NYHA) class II

• Left ventricular ejection fraction (LVEF) <= 40%

• Age 20-80 years

Exclusion Criteria:

• Necessity of short-term PCI, CABG or heart transplantation,

• Chronic disease of the autonomic nervous system,

• diabetes mellitus,

• use of tricyclic antidepressant drugs and/or a-adrenergic receptor antagonists.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

• Heart Failure

Intervention

Drug:
• vitamin C

• placebo

Locations

Country	Name	City	State
Netherlands	Radboud University Nijmegen Medical Centre	Nijmegen

Sponsors (2)

Lead Sponsor	Collaborator
Radboud University	ZonMw: The Netherlands Organisation for Health Research and Development

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in central sympathetic output after vitamin C vs. placebo