Heart Failure Clinical Trial
Official title:
Risk Stratification and Benefits With Cardiac Resynchronization Therapy
This is an observational study to learn which patients benefit from CRT therapy and to track the clinical changes that help identify the risk-level of CRT patients.
The purpose of the study is two-fold. First, to determine if an algorithm can be developed
based on pre-implant clinical variables to predict response to CRT-D therapy. Second, the
study aims to determine in patients implanted with CRT-D if the combined use of cTnT and BNP
can further predict and risk-stratify HF improvement and all-cause mortality. Additionally,
novel biochemical markers defining cardiac mortality in high risk patients detected by plasma
proteomic analysis in the CRT-D patients will be evaluated.
This study represents a combination of previous CRT studies that evaluated these variables
independently. Data from this study will be pooled with data from previous studies to build a
more complete picture of CRT therapy.
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