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Clinical Trial Summary

Heart failure impairs quality of life and exercise capacity, despite an optimal medical therapy. Alternative methods, like hypoxic conditioning coupled to exercise training, must be explored and describe


Clinical Trial Description

All heart failure patients will have a session of 45' of bicycle exercise training (in normoxia or hypoxia) AND a one hour rest session (in normoxia or hypoxia).

Exercise training sessions will consist in a continue bicycle exercise test at 70 to 80 % of the maximal heart rate, while breathing (single blind) normoxia or hypoxia gaz.

Rest conditioning consist in a one hour of rest, while breathing (single blind) normoxia or hypoxia gaz.

For hypoxia sessions, the oxygen saturation target will be fo 85-90 % for the 4 first weeks and 80-85 % for the last 4 weeks.

Three arms :

- exercise training in NORMOXIA and rest conditioning in NORMOXIA

- exercise training in HYPOXIA and rest conditioning in NORMOXIA

- exercise training in NORMOXIA and rest conditioning in HYPOXIA ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03537079
Study type Interventional
Source University Hospital, Grenoble
Contact stephane doutreleau, MD, PhD
Phone + 33 4 76 76 77 73
Email sdoutreleau@chu-grenoble.fr
Status Recruiting
Phase N/A
Start date May 2020
Completion date May 2022

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