Heart Failure Patients Clinical Trial
Official title:
" Prognostic Value of Soluble ST2 Beyond B-Type Natriuretic Peptide in Management of Patients With Heart Failure"
1. The aim of this study was to explore the relationship between peripheral circulating serum soluble suppression of tumorigenicity-2 (sST2) levels and inflammatory biomarkers in patients with heart failure 2. Additive role of sST2 to NPs in of heart failure patients
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | January 1, 2027 |
Est. primary completion date | July 1, 2026 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - patients 18-80 years. - Both sexes will be included. - including signs and symptoms of HF (e.g., elevated jugular venous pressure and altered apical beat position), altered LVEF (< 40%; 40%-49%; = 50%) Exclusion Criteria: - Patients <18 years - Patients with documented evidence of cardiogenic shock . - Patients with Acute coronary syndrome within 30 days. - chronic kidney disease patients with glomerular filtration rate < 30 - Patients with interstitial pulmonary fibrosis . |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Purdy GE, Payne SM. The SHI-3 iron transport island of Shigella boydii 0-1392 carries the genes for aerobactin synthesis and transport. J Bacteriol. 2001 Jul;183(14):4176-82. doi: 10.1128/JB.183.14.4176-4182.2001. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To evaluate if Soluble ST2 is strongly associated with measures of HF severity and poor outcome | Study ST2 level in heart failure patients and correlate results with clinical data and other inflammatory biomarker | Baseline | |
Primary | Evaluation of BNP and ST2 could have a potential role in prognosis. | Study value of BNP in prognosis and compare it with ST2 | Baseline | |
Secondary | • Clinical Impact and Treatment Decision Support | Evaluate ST2 as a novel biomarker which provide risk stratification of patients with acute and chronic HF beyond BNPs | Baseline |
Status | Clinical Trial | Phase | |
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Completed |
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