Heart Failure, Congestive Clinical Trial
Official title:
Effects of Adaptive Servoventilation in Patients With Systolic Heart Failure and Sleep-Disordered Breathing
Prospective, follow-up registry of heart failure patients with or without sleep-disordered breathing (SDB). To test the hypothesis that treatment of nocturnal central sleep apnea with Cheyne-Stokes respiration by adaptive servoventilation (ASV) improves symptoms, cardiac performance and event-free survival.
The study is intended to investigate therapeutic effects of adaptive servoventilation in
patients with sleep-disordered breathing and chronic heart failure. These effects include
short-/long-term effects on
- symptoms and quality of life
- physical and cardiac performance (6min walking test, cardiopulmonary exercise testing)
- echocardiographic parameters
- arrhythmias
- NT-proBNP
- Respiratory stability (blood gases, rebreathing test, VE/VCO2-slope in cardiopulmonary
exercise testing)
- Compliance with ASV therapy
- Event free survival (death, heart transplantation, assist device implantation)
All of these data are also obtained in patients who basically meet the inclusion criteria but
in whom sleep-disordered breathing was excluded by means of cardiorespiratory polygraphy or
polysomnography and in patients with sleep-disordered breathing who do not undergo adaptive
servoventilation for various reasons.
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