Cardiovascular Responses in Congestive Heart Failure With Cheyne- Stokes Respiration

Heart Failure, Congestive Clinical Trial

Official title:

Cardiovascular Response to Peripheral Chemoreceptor Stimulation in Congestive Heart Failure With Cheyne- Stokes Respiration

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00495196
• Other study ID #: X07-0079
• Status: Completed
• Phase: N/A
• First received: June 28, 2007
• Last updated: July 25, 2010
• Start date: June 2007
• Est. completion date: March 2010

Study information

• Verified date: July 2010
• Source: ResMed
• Contact: n/a
• Is FDA regulated: No
• Health authority: Australia: Department of Health and Ageing Therapeutic Goods Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of the trial is to investigate the cardiovascular response to peripheral chemoreceptor stimulation in Congestive Heart Failure with Cheyne- Stokes Respiration

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: March 2010
• Est. primary completion date: March 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Moderate to severe heart failure (NYHA Class II or above) on optimal medical therapy

• LVEF less than or equal to 45%

• Stable condition as defined as no hospital admission or changes to medical therapy within two weeks prior to enrolment

Exclusion Criteria:

• Patients taking known respiratory stimulants or depressants

• Clinically significant asthma requiring therapy

• Significant parenchymal lung disease

• Primary pulmonary hypertension

• Myocardial infarction within three months prior to enrolment

• Patients with cardiac resynchronisation devices and permanent pacemakers

• Anaemic (haemoglobin < 12g/dL)

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Cheyne-Stokes Respiration
• Heart Failure
• Heart Failure, Congestive

Intervention

Procedure:
• Experimental lung function test
Administration of several CO2 gas mixtures

Locations

Country	Name	City	State
Australia	Royal Prince Alfred Hospital	Camperdown	New South Wales

Sponsors (1)

Lead Sponsor	Collaborator
ResMed

Country where clinical trial is conducted

Australia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cardiovascular parameters such as continuous blood pressure and heart rate.		During administration of the intervention	No