Diuretic Efficacy of Dexamethasone in Heart Failure

Status Suspended

Clinical Trial Summary

The purpose of this study is to determine whether glucocorticoids have potent diuretic effects in patients with congestive heart failure.

Clinical Trial Description

Glucocorticoids are known to have pronounced physiological effects in the kidney. Conventional teaching dictates that it should be used with caution in patients with congestive heart failure due to its fluid and sodium retention effects. Surprisingly, despite the widespread prevalence of this belief within the medical community, there are few data to support it. In fact, several small animal studies have documented its striking diuretic effects due to increased renal plasma flow and glomerular filtration rate without changes in the glomerular filtration fraction. We design this study to determine whether glucocorticoids have a potent diuretic effect in patients with heart failure. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00263302
Study type	Interventional
Source	Hebei Medical University
Contact
Status	Suspended
Phase	Phase 1
Start date	March 2006
Completion date	December 2006

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