Evaluate the Predictive Impact of the MEESSI Score

Heart Diseases Clinical Trial

— MEESSI  

Official title:

Evaluate the Predictive Impact of the Meessi MEESSI Score for the Risk Stratification of Patients Admitted for Acute Heart Failure in Emergency Department

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05340972
• Other study ID #: MEESSI 2022
• Status: Recruiting
• Start date: January 15, 2009
• Est. completion date: May 30, 2023

Study information

• Verified date: May 2023
• Source: University of Monastir
• Contact: Semir Nouira, Professor
• Phone: 7310600
• Email: semir.nouira[@]rns.tn
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Our primary purpose is to assess MEESSI score in predicting mortality and readmission of patients managed for acute heart failure (AHF) in Emergency Department.

European Society of Cardiology recommend risk stratification for patients with AHF.

Description:

Improved risk stratification of acute heart failure (AHF) in the emergency department (ED) may help physicians' decisions regarding patient admission or early discharge disposition. The MEESSI-AHF (Multiple Estimation of risk based on the Emergency department Spanish Score In patients with AHF) score was developed to predict 30-day mortality in patients presenting with AHF EDs in Spain. Whether it performs well in other countries is unknown.

The MEESSI-AHF risk model includes 13 variables readily available on arrival to Emergency Department. The 40% of patients classified as LOW RISK (30-day mortality: <2%) should be considered as potential candidates to be early discharged from Emergency Department without admission after adequate response to initial treatment. The 10% of patients classified as VERY HIGH RISK (30-day mortality: >2%) may clearly benefit from hospital admission.

Objective: To externally validate the MEESSI-AHF score in another country.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1500
• Est. completion date: May 30, 2023
• Est. primary completion date: May 30, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 95 Years

Eligibility

Inclusion Criteria:

• Major patient

• Patient admitted to emergencies with final diagnosis of AHF according to the opinion of two emergency experts after consulting the data from the clinical examination, cardiac echocardiography, and BNP level.

• Subject who accept to participate in the research

Exclusion Criteria:

• Patient who refuse to participate in the study

• Patient with coronary syndrome with ST segment elevation

• Other causes of dyspnea

• Impossibility of giving the patient informed information

• Pregnant woman

Related Conditions & MeSH terms

• Emergencies
• Heart Diseases

Intervention

Diagnostic Test:
• MEESSI score
The score aimed to predict the AHF patient's future in the month following management for ED

Locations

Country	Name	City	State
Tunisia	Emergency department of University hospital Fattouma Bourguiba	Monastir

Sponsors (1)

Lead Sponsor	Collaborator
University of Monastir

Country where clinical trial is conducted

Tunisia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MEESSI score	predict the AHF patient's future in the month following management in ED with The MEESSI (Multiple Estimation of risk based on the Emergency department Spanish Score In patients with AHF).The MEESSI-AHF risk model includes 13 variables readily available on arrival to Emergency Department. The 40% of patients classified as LOW RISK (30-day mortality: <2%) should be considered as potential candidates to be early discharged from Emergency Department without admission after adequate response to initial treatment. The 10% of patients classified as VERY HIGH RISK (30-day mortality: >2%) may clearly benefit from hospital admission.	30 days
Secondary	Re-admission rate [ Time Frame: 30 days ]	30-day re-admission rate compared between the 4 risk categories defined by the MEESSI score	30 days
Secondary	Mortality rate [ Time Frame: 30 days ]	Mortality rate at 30 days compared between the 4 risk categories defined by the MEESSI score	30 days
Secondary	Sensitivity [ Time Frame: 30 days ]	Sensitivity, specificity and ROC curve of the MEESSI score in relation to the composite criterion according to the 4 risk categories	30 days