Heart Defects, Congenital Clinical Trial
OBJECTIVES: I. Identify latent hypoparathyroidism in normocalcemic adult survivors with
repaired conotruncal cardiac defects, by evaluating parathyroid gland secretory function
after induced hypocalcemia.
II. Determine the relationship of parathyroid hormone secretion to microdeletions in the
same region of chromosome 22q11 as found in patients with DiGeorge anomaly.
PROTOCOL OUTLINE:
Patients are given sodium citrate over a 2 hour infusion on day 1. Blood is drawn at times
-30, -15, 0, and every 10 minutes thereafter during the infusion. On day 2, patients are
given calcium gluconate over a 2 hour infusion. Blood is drawn at times -30, -15, 0, and
every 10 minutes thereafter during the infusion.
;
Primary Purpose: Screening
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