Heart Arrest Clinical Trial
Official title:
Study of Myocardial Contractility After Cardiac Surgery Under an Anterograde or Retrograde Cardioplegia
Myocardial protection is a fundamental element for the safety of patients when performing
cardiac surgery. For this purpose, cardioplegia were rapidly established in clinical practice
to protect the myocardium when performing aortic clamp.
Cardioplegia are procedures to stop the contraction of myocardium. It is usually achieved
with the use of chemicals ( cardioplegic solutions) or cold temperature (such as chilled
perfusate). The composition of the cardioplegic solutions and their method of administration
continuously changed over the years.
At the present date, cold blood cardioplegias are performed in the investigator's center. The
investigators regularly use two modes of administration: either by an antegrade path
(injection in the coronary arteries), or a retrograde one (injection in the venous system).
At present, there are no elements supporting the superiority or inferiority of one path
compared to another. The difficulty lies within a clear estimation of the contractility state
of the ventricular cardiac muscle.
Technological developments in recent years provided a solution to this problem. The analysis
of the pressure/volume curves generated by a ventricle allows an accurate quantification of
the myocardial contractility. This requires the use of conductance catheters to accurately
measure the ventricular volume and the ventricular pressure. The absolute ventricular
contractility is then deduced with the help of a software.
The investigators intend to use this pressure-volume loops, obtained with conductance
catheters, to compare the contractility of the right heart ventricle after antegrade vs
retrograde cardioplegia.
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