Healthy Clinical Trial
Official title:
Dairy Products to Your Gut and Brain
The goal of this intervention study is to compare the effects of fermented dairy and non-fermented dairy on bowel habits and cognitive performance in healthy women with defecations every other day or less. Furthermore, the study aims to explore underlying mechanisms linking the gut and the brain. In addition, a sub-study will be conducted to explore differences in gut and brain measures between women with daily (reference group) and few (intervention group) weekly bowel movements, respectively, and to explore associations between measures of gut- and brain function.
Participants in the intervention study (n=60) will consume 300g of fermented dairy (yogurt) or non-fermented dairy (milk) daily for 4 weeks. After a washout period of at least 4 weeks, the participants will consume the alternative dairy product (yogurt or milk) for 4 weeks. The participants will collect samples at home and be tested at the institute before and after each condition (yogurt or milk). Participants in the sub-study (n=40) will not undergo any dairy interventions and they will only take part in the baseline assessments. Prior to all visits at the institute, the participants are asked to complete some study activities at home, including: - consumption of sweet corns to estimate whole gut transit time - collection of fecal- and urine samples - measurement of methane and hydrogen in breath - reporting of gastrointestinal symptoms, including stool frequency and Bristol Stool Scale During all visits at the institute, the participants will undergo tests and measurements, including: - measurement of methane and hydrogen in fasting breath - collection of fasting blood samples - completion of cognitive tests - recordings of electrophysiological signals of the gut and the brain - completion of questionnaires assessing mood, quality of life, and physical activity, among others ;
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