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Continuous Measurement of Glymphatic Activity in the Human Brain During Sleep-Wake States

Healthy Clinical Trial

Official title:
Continuous Measurement of Glymphatic Activity in the Human Brain During Sleep-Wake States

Clinical Trial Summary

This is a cross-over randomized study to validate the Sponsor investigational medical device against measurements of glymphatic function from MRI-based neuroimaging, EEG, blood biomarkers and cognitive tests in healthy older volunteers.

Clinical Trial Description

The study population will consist of healthy individuals, ages 50 to 65, that are cognitively normal and do not have a medical history of neurological or sleep disorder, cardiovascular disease, hypertension, or diabetes. The objectives of this study are to define whether sleep- and wake-associated device measurements (i) faithfully reflect glymphatic function measured by non-invasive MRI measures of glymphatic function; (ii) replicate pre-clinical findings between sleep EEG power bands and glymphatic flow; (iii) predict plasma levels of Alzheimer's disease (AD)-related biomarkers; and (iv) predict morning cognitive performance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06060054
Study type Interventional
Source Applied Cognition
Contact
Status Completed
Phase N/A
Start date November 1, 2022
Completion date May 10, 2023
View Details
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