The Anabolic and Catabolic Effect of Loaded and Unloaded Exercise on Articular Cartilage Health

Healthy Clinical Trial

Official title:

A Preliminary Study on the Effect of Loaded and Unloaded Exercise on Anabolic and Turnover Activity of Articular Cartilage in Healthy Young Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05925244
• Other study ID #: HS22322
• Status: Completed
• Phase: N/A
• Start date: September 27, 2019
• Est. completion date: March 1, 2020

Study information

• Verified date: June 2023
• Source: University of Manitoba
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: March 1, 2020
• Est. primary completion date: March 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Healthy

• 18-30 years old

Exclusion Criteria:

• Traumatic injury to the lower extremity in the past year

• Hip, knee, or ankle surgery

• Radiographic evidence of joint degeneration

• Cardiovascular disease

• Ankylosing spondylitis

• Psoriatic arthritis

• Chronic reactive arthritis

• Renal problems requiring peritoneal dialysis or hemodialysis

• Not currently using any prescription or non-prescription medications and/or nutritional supplements

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Control Condition
Control (no alteration to body mass).
• +12% Body Mass
Loaded walking exercise (12% increase in body mass using a weighted vest).
• -12% Body Mass
Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).

Locations

Country	Name	City	State
Canada	University of Manitoba	Winnipeg	Manitoba

Sponsors (1)

Lead Sponsor	Collaborator
University of Manitoba

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Serum cartilage oligomeric matrix protein (sCOMP)	The systemic blood serum concentration of sCOMP was evaluated in all participants under the 3 conditions in a crossover trial.	sCOMP was measured at baseline, immediately post, and 15- and 30-minutes post exercise.
Primary	N-propeptide of type II collagen (PIIANP)	The systemic blood serum concentration of PIIANP was evaluated in all participants under the 3 conditions in a crossover trial.	PIIANP was measured at baseline, immediately post, and 15- and 30-minutes post exercise.