The Effects of Manual Lymphatic Drainage on the Autonomic Nerve System

Healthy Clinical Trial

Official title:

Does Manual Lymph Drainage Affect Autonomic Functions in Healthy Women?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05809726
• Other study ID #: 2021/03-06
• Status: Completed
• Phase: N/A
• Start date: July 15, 2021
• Est. completion date: May 15, 2022

Study information

• Verified date: January 2023
• Source: Kutahya Health Sciences University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Forty healthy women who met the inclusion criteria were included in the study. In the single-blind randomized controlled study, the participants were divided into 3 groups manual lymphatic drainage(MLD), sham MLD, and control group. After evaluating the demographic information, blood pressure, and heart rate variability (HRV) of the participants, the cold pressure test was applied. Immediately after the test, blood pressure and HRV were re-evaluated. The MLD group received short neck, abdominal, and lymph node stimulation and right arm MLD applications. A sham protocol was applied to the sham MLD group. The control group was asked to lie on their back for 10 minutes. After the application, blood pressure and HRV were re-evaluated.

Description:

The participants included in the study were randomly divided into 3 groups; manual lymph drainage, sham manual lymph drainage, and a control group in the computer program.

Participants rested for 5 minutes before the first evaluation. The first evaluation was made after the demographic information of the participant was obtained. Within the scope of this evaluation, blood pressure, heart rate, and heart rate variability were evaluated. All assessments were performed on the patient's dominant upper extremity. After the evaluation, cold pressure test was applied to the dominant extremity. A second assessment was made immediately after the test. All of the parameters examined within the scope of the first evaluation were examined for the second time. Appropriate treatment was applied to the group to which the participant belonged. After the treatment, the third evaluation was made and the study was terminated. All participants were asked to avoid exercise, caffeine, energy drinks, and heavy meals at least 1 hour before the test. Environmental noise, light, and temperature were controlled during the test.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: May 15, 2022
• Est. primary completion date: January 15, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• being over 18 years of age

• being voluntary to participate in the study

Exclusion Criteria:

• having advanced cardiorespiratory diseases

• orthopedic and neurological problems

• using medication related to pain

• cardiovascular system, having skin disorders that prevent skin contact

• having cold urticaria

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Manual lymph drainage
one session 20 minutes

Locations

Country	Name	City	State
Turkey	Kutahya Health Sciences University	Kütahya	Kutahya

Sponsors (1)

Lead Sponsor	Collaborator
Kutahya Health Sciences University

Country where clinical trial is conducted

Turkey, 

References & Publications (3)

Honguten A, Mekhora K, Pichaiyongwongdee S, Somprasong S. Effects of lymphatic drainage therapy on autonomic nervous system responses in healthy subjects: A single blind randomized controlled trial. J Bodyw Mov Ther. 2021 Jul;27:169-175. doi: 10.1016/j.jb — View Citation

Kim SJ, Kwon OY, Yi CH. Effects of manual lymph drainage on cardiac autonomic tone in healthy subjects. Int J Neurosci. 2009;119(8):1105-17. doi: 10.1080/00207450902834884. — View Citation

Schingale FJ, Esmer M, Kupeli B, Unal D. Investigation of the Less Known Effects of Manual Lymphatic Drainage: A Narrative Review. Lymphat Res Biol. 2022 Feb;20(1):7-10. doi: 10.1089/lrb.2019.0091. Epub 2021 Mar 22. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	autonomic functions assessment	heart rate variability	1 year
Primary	physiological parameter	Systolic blood pressure (mmHg) and diastolic blood pressure (mmHg)	1 year