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Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought

Healthy Clinical Trial

Official title:
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought

Clinical Trial Summary

This research study will use computerized tasks, electroencephalography (EEG), and magnetic resonance imaging (MRI) to look at how the drug psilocybin, a naturally occurring compound contained in hundreds of species of psychoactive mushrooms, changes thoughts and brain activity.

Clinical Trial Description

In this double-blind, placebo-controlled, within-subject, full cross-over study in healthy volunteers, computerized, electroencephalography (EEG), and magnetic resonance imaging (MRI) measures will be assessed to test the acute effects of a moderate dose of psilocybin (10 mg/70 kg) on creativity, the contents and dynamics of thought, memory, and shared vs individual brain response while viewing naturalistic stimuli. Understanding the acute psychological and neural effects of psychedelic drugs such as psilocybin may allow for future optimization of psychedelic medicine, as well as a deeper and more refined understanding of consciousness itself. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05301608
Study type Interventional
Source Johns Hopkins University
Contact Gabi Lofland
Phone (410) 550-2253
Email gloflan1@jhmi.edu
Status Recruiting
Phase Phase 1/Phase 2
Start date March 3, 2022
Completion date December 31, 2024
View Details
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