Comparison of Water Sorption Capacity and the Composition of Bronchial Fluids of Healthy Persons and Patients With Chronic Obstructive Bronchitis (COPD)

Healthy Clinical Trial

Official title:

Vergleich Der Wasseraufnahmefähigkeit Und Zusammensetzung Von Bronchialflüssigkeiten Von Gesunden Und Patienten Mit Chronisch Obstruktiver Bronchitis (COPD)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04703023
• Other study ID #: MUCUS2020
• Status: Completed
• Start date: July 9, 2020
• Est. completion date: May 17, 2023

Study information

• Verified date: May 2023
• Source: Institut für Pneumologie Hagen Ambrock eV
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Pilot basic research study on the properties of bronchial mucus. Examination of the sorption and desorption properties, mucin concentration, and structure of the mucus from healthy airways compared to patients with Chronic Obstructive Pulmonary Disease (COPD).

Description:

Mucus, of the correct composition, maintains airway hydration and protects the airway from inhaled particles through mucociliary transport. In chronic inflammatory airway diseases such as COPD or cystic fibrosis, infectious agents, inflammatory cells and products of inflammation such as DNA, increase mucus viscosity which results in decreased mucociliary clearance of inhaled particles, increasing the likelihood of respiratory infections. This pilot study is planned as basic research on the properties of bronchial mucus.

Water isotherms and efficient water activity (sorption and desorption) of the collected samples are examined in defined temperature and humidity settings using DVS Intrinsic (Dynamic Vapour Sorption System, Surface Measurement Systems, London, UK). Findings will provide insights into possible treatment programs targeted at altering specific mucus components.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 31
• Est. completion date: May 17, 2023
• Est. primary completion date: May 2, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age>18

• COPD or other disease requiring bronchoscopy or elective surgery

• Signed informed consent form

Exclusion Criteria:

• Not able to consent

• Linguistic, cognitive, or other obstacles

Related Conditions & MeSH terms

• Bronchitis
• COPD
• Healthy

Locations

Country	Name	City	State
Germany	Kliniken Essen-Mitte, Evang. Huyssens-Stiftung/Knappschaft gGmbH	Essen	NRW

Sponsors (1)

Lead Sponsor	Collaborator
Georg Nilius, Prof DR med

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sorption	Maximum water sorption per degree of saturation in percent of the dry mass weight of the mucus samples	5 days