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Study of ALXN2050 in Participants With Renal Impairment

Healthy Clinical Trial

Official title:
A Phase 1, Open-Label, Multiple-Dose, Parallel Study to Determine the Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of ALXN2050 in Adult Participants

Clinical Trial Summary

This study will investigate the impact of impaired renal function on the plasma pharmacokinetics of ALXN2050 in order to provide dosing recommendations for future indications in individuals with impaired renal function.

Clinical Trial Description

The study will initiate (Part 1) with participants with severe impaired renal function (Cohort 1) and their matched healthy control participants (Cohort 4). Following data review, the study may proceed (Part 2) with participants with moderate (Cohort 2) and mild (Cohort 3) impaired renal function if deemed necessary. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04623710
Study type Interventional
Source Alexion
Contact
Status Completed
Phase Phase 1
Start date July 8, 2021
Completion date March 21, 2022
View Details
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