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The Effects of Losartan on Reward Reinforcement Learning

Healthy Clinical Trial

Official title:
The Role of the Renin-angiotensin System in Reward Reinforcement Learning

Clinical Trial Summary

This study aims to investigate whether a single dose of losartan (50 mg) can affect learning from positive and negative outcomes and its related neural mechanisms.

Clinical Trial Description

Emerging evidence suggests that the renin-angiotensin system can impact dopamine (DA) transmission and its modulatory role in reward processing. For instance, recent animal models have found that the angiotensin antagonist losartan reduces rewarding effects of methamphetamine and nicotine by modulating DA release in the striatum.The present study thus will investigate losartan effects on reward reinforcement learning and the underlying neural mechanisms. In a double-blind, between-subject, placebo-controlled design, 60 healthy male subjects will be randomly assigned to receive single-dose losartan (50 mg) or placebo, 90 minutes before performing a probabilistic reinforcement learning task during fMRI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04604938
Study type Interventional
Source University of Electronic Science and Technology of China
Contact Weihua Zhao, PhD
Phone 86-28-61830811
Email zarazhao.uestc@outlook.com
Status Recruiting
Phase N/A
Start date October 10, 2020
Completion date March 31, 2022
View Details
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