The Effect of Transcranial Direct Current Stimulation on Motor Performance in Healthy Adults

Healthy Clinical Trial

Official title:

The Effect of Transcranial Direct Current Stimulation Intensity on Motor Performance in Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04577768
• Other study ID #: AU-HEA-SFT-20190326
• Status: Completed
• Phase: N/A
• Start date: July 11, 2019
• Est. completion date: February 10, 2020

Study information

• Verified date: September 2020
• Source: Ariel University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

to investigate the effect of stimulation intensity on motor performance in healthy adults.

Description:

60 healthy subjects were randomly allocated to one of three groups: (a) 20-min of High-Definition transcranial direct current stimulation (HD-tDCS) with an intensity of 2 mA (HD-tDCS 2 mA); (2) 20-min of HD-tDCS with an intensity of 1.5 mA (HD-tDCS 1.5 mA); and (3) 20-min of sham HD-tDCS (HD-tDCS sham). The stimulation was administered noninvasively using an M x N 9-channel high definition transcranial electrical current stimulator from Soterix Medical (New York, NY). The anodal stimulation targeted the right Brodmann area 4 (primary motor cortex) based on HD-Targets brain modelling software (Soterix Medical, New York, NY).

Tests: The non-dominant left arm was tested. The subjects performed a sequential point-to-point movement task on the graphics tablet. Initially, the participants were required to perform 3 sequences without errors to familiarize themselves with the setup, the task and the sequence. Then, they performed the pre-test which consisted of two blocks of 6 sequences, i.e. 12 sequences, with a 30 s break between blocks. Two min after starting the appropriate stimulation, they performed 2 blocks of 6 sequences (identical to the pre-test). After finishing the tDCS stimulation, the participants performed a post-test, which was also identical to the pre-test. The participants returned after 24 hours to perform a retention test, which was equivalent to the pre- and post-tests. Two outcome measures were used: movement time (s) and the reaction time (s) of the reaching movements.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: February 10, 2020
• Est. primary completion date: February 10, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 35 Years

Eligibility

Inclusion Criteria:

• aged between 20 and 35

• right-hand dominant

• healthy according to self report

Exclusion Criteria:

• taking psychiatric medications

• a history of drug abuse or dependence

• psychiatric or neurological disorder

• a history of seizures

• metal implants in their head

• musculoskeletal deficits interfering with task performance (proper reaching performance in sitting)

Related Conditions & MeSH terms

• Healthy

Intervention

Device:
• HD-tDCS 2 mA
anodal high definition transcranial direct current stimulation of the right primary motor cortex with an intensity of 2 mA
• HD-tDCS 1.5 mA
anodal high definition transcranial direct current stimulation of the right primary motor cortex with an intensity of 1.5 mA
• HD-tDCS sham
sham stimulation of the right primary motor cortex

Locations

Country	Name	City	State
Israel	Ariel University	Ariel

Sponsors (2)

Lead Sponsor	Collaborator
Ariel University	Tel Aviv University

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in movement time (s) from baseline to intervention	Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.	Baseline (immediately before stimulation), two minutes after starting the stimulation
Primary	Change in movement time (s) from baseline to posttest	Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.	Baseline (immediately before stimulation), immediately post stimulation
Primary	Change in movement time (s) from baseline to retention test	Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.	Baseline (immediately before stimulation), 24 hours following the stimulation
Primary	Change in movement time (s) from intervention to posttest	Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.	Two minutes after starting the stimulation, immediately post stimulation
Primary	Change in movement time (s) from intervention to retention test	Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.	Two minutes after starting the stimulation, 24 hours following the stimulation
Primary	Change in movement time (s) from posttest to retention test	Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.	immediately post stimulation, 24 hours following the stimulation
Primary	Change in reaction time (s) from baseline to intervention	Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.	Baseline (immediately before stimulation), two minutes after starting the stimulation
Primary	Change in reaction time (s) from baseline to posttest	Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.	Baseline (immediately before stimulation), immediately post stimulation
Primary	Change in reaction time (s) from baseline to retention test	Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.	Baseline (immediately before stimulation), 24 hours following the stimulation
Primary	Change in reaction time (s) from intervention to posttest	Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.	Two minutes after starting the stimulation, immediately post stimulation
Primary	Change in reaction time (s) from intervention to retention test	Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.	Two minutes after starting the stimulation, 24 hours following the stimulation
Primary	Change in reaction time (s) from posttest to retention test	Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.	immediately post stimulation, 24 hours following the stimulation