Healthy Clinical Trial
Official title:
Characterization of Cerebral Tau Aggregates With 18F-RO6958948 PET in the ALFA Population
This study will characterize tau tracer retention by Positron Emission Tomography (PET) as a function of amyloid levels transversally and longitudinally.
CROSS-SECTIONAL OBJECTIVES - To measure 18F-RO6958948 retention in selected participants of ALFA-related studies as a function of amyloid levels. - To study the relation between 18F-RO6958948 retention and amyloid levels. - To characterize imaging correlates as a function of tau and amyloid levels. - To study the role of tau retention on cognitive performance. - To define predictors of tau retention. LONGITUDINAL OBJECTIVES - To measure tau accumulation and spreading in participants of the ALFA-related studies of BBRC as a function of baseline amyloid levels. - To study the dynamic relation between tau spreading and amyloid levels longitudinally. - To define predictors of tau spreading. ;
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