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CBD-Microglia PET Study

Healthy Clinical Trial

Official title:
Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization

Clinical Trial Summary

This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects.

Clinical Trial Description

This study aims to examine the effect of cannabidiol (CBD), pre-treatment, as Epidiolex, on brain microglial activation in healthy human subjects using [11C]PBR28 PET imaging. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects. Lastly, this research study will also examine the relationship between brain microglial activation and central pain sensitization with CBD pre-treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04398719
Study type Interventional
Source Yale University
Contact Rajiv Radhakrishnan, MD
Phone 203-974-7489
Email rajiv.radhakrishnan@yale.edu
Status Recruiting
Phase Early Phase 1
Start date May 7, 2021
Completion date March 1, 2025
View Details
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