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Siderophore-profile in Allergic and Non-allergic Subjects

Healthy Clinical Trial

Official title:
Linking Iron-deficiency With Allergy- the Role of Microbial Survival Components

Clinical Trial Summary

This study aims to profile the siderophore-content in the human gut from allergic and non-allergic subjects and to assess their contribution in iron homeostasis.

Clinical Trial Description

Iron is an essential nutrient for the majority of commensal bacteria, which commonly secrete siderophores to liberate iron from their surroundings. In several studies, a misbalanced microbiota has been demonstrated in allergics suggesting that also their siderophore profile is severely attenuated. There are currently no data and very limited knowledge present on the composition of bacterial surviving factors in humans, or on their impact on the human immune system. As such, 1) the iron status, 2) the microbial biota composition and the 3) siderophore-profile in allergics and non-allergics will be assessed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03815981
Study type Observational
Source Medical University of Vienna
Contact
Status Completed
Phase
Start date December 12, 2018
Completion date December 12, 2021
View Details
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