Dietary Nucleotides and Ribose on Muscle Fuel Utilisation

Healthy Clinical Trial

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Official title:

The Effect of Dietary Nucleotides and Ribose on Muscle Fuel Utilisation and Exercise Performance

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03659890
• Other study ID #: 171206/B/04
• Status: Completed
• Phase: N/A
• Start date: June 28, 2018
• Est. completion date: February 2, 2020

Study information

• Verified date: March 2020
• Source: University of Exeter
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Nucleotides are the building blocks for a variety of molecules, including ATP, which is broken down in the skeletal muscle cells to provide fuel for exercise. Nucleotides can be obtained from the diet, and produced or salvaged by the body. Though nucleotides provide the building blocks for ATP, the sugar ribose has been suggested to be rate limiting for synthesising ATP.

Previous studies have shown a decrease in ATP levels in the muscle after intense exercise, and this is linked to fatigue. Other studies have also reported benefits of nucleotide and/or ribose supplementation on exercise performance. However, any potential link between ATP metabolism and exercise performance has not been explored.

This study will look at the effects of nucleotide and nucleotide-ribose supplementation in fuel utilisation and performance in skeletal muscle during endurance exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: February 2, 2020
• Est. primary completion date: February 2, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• BMI between 18 and 30

Exclusion Criteria:

• On medication (except contraception)

• Smokers

• Diagnosed with any metabolic or cardiovascular conditions

• Muscle or bone injuries

• BMI < 18 or > 30

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• Low nucleotide
2 week, twice daily, supplementation with a nucleotide-depleted mycoprotein drink, with added dextrose
• High nucleotide
2 week, twice daily, supplementation with a nucleotide-rich mycoprotein drink, with added dextrose
• High nucletide + Ribose
2 week, twice daily, supplementation with a nucleotide-rich mycoprotein drink, with added ribose

Locations

Country	Name	City	State
United Kingdom	University of Exeter - St Luke's Campus	Exeter	Devon

Sponsors (1)

Lead Sponsor	Collaborator
University of Exeter

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in muscle ATP concentrations		After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery
Secondary	Changes in muscle glycogen concentrations		After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery
Secondary	Blood lactate concentrations		After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise
Secondary	Blood glucose concentrations		After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise
Secondary	Serum uric acid concentrations		Measured at baseline and of days 6, 8 and 15 of each supplementation cycle