Healthy Clinical Trial
Official title:
Pharmacokinetic Study to Assess and Compare the Pharmacokinetics of Enrofloxacin After Dermal, Inhaled, and Oral Dosing
Antibiotics like enrofloxacin are widely used in animal farming to treat and prevent bacterial infections. A previous study in poultry farms has shown that yardmen show significant concentrations of administered antibiotics in their urine. It is currently unclear how poultry yardmen are exposed to the administered antibiotics. The objective of this exemplarily study is to obtain information on the pharmacokinetics of the different uptake routes (oral, inhaled or dermal).
Study subjects will be exposed to enrofloxacin at a concentration level representative for
occupational exposure of yardmen at poultry farms.
As three uptake-routes, oral, inhalation and dermal, are conceivable all three cases will be
investigated. After administration blood and urine samples will be analysed for enrofloxacin
and its main metabolite ciprofloxacin at several time points. The objective of this
exemplarily study is to obtain information on the pharmacokinetics of the different uptake
routes. If different exposure routes are characterized by different pharmacokinetics, such
studies can be used to obtain a better understanding of general routes of exposure in
occupational environments. On the basis of the results mitigation strategies can be
developed, reducing the risk of exposure.
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