Healthy Clinical Trial
Official title:
Development of an EEG Analytics Tool to Determine Effectiveness of a tDCS Protocol
The goal of this study is to monitor the brain using electroencephalography (EEG) while transcranial direct current stimulation (tDCS) is being administered, as a potential pathway to determine neurophysiological markers capable of forecasting the intensity of a subject's response to tDCS.
Transcranial direct current stimulation is a non-invasive neuromodulation technique that has
been the subject of many recent investigations. There is a growing body of evidence to
suggest that tDCS can enhance the efficacy of various therapies. However, progress in the
field is slow: many studies suffer from reproducibility issues, or highly variable results,
including stroke rehabilitation. It is feasible that much of the variance in experimental
results can be explained by an inability to quantitatively track individual responses to tDCS
in real-time, and personalize stimulation parameters for maximum effect.
Monitoring the brain via EEG while tDCS is being administered is a potential pathway to
determine neurophysiological markers capable of forecasting the intensity of a subject's
response to tDCS. This research has not previously been attempted due to technical
difficulties- namely, the electromagnetic interference that is associated with tDCS degrades
EEG signal quality. Recent advances in electrode and amplification technology have made it
possible to make EEG recordings simultaneously with tDCS.
The investigators will attempt to determine whether specific EEG signatures can indicate the
magnitude of a tDCS response. Subjects will receive either real or sham anodal tDCS to the
hand representation of their left primary motor cortex.
The efficacy of the tDCS protocol will be quantitatively determined using transcranial
magnetic stimulation (TMS) to generate a motor-evoked potential (MEP) in the hand pre- and
post-tDCS. Additionally, prior to, during, and following the tDCS protocol, we will record
EEG event-related potentials (ERPs) in response to a finger-tapping (motor) task.
The investigators aim to draw a correlation between the magnitude of MEP changes and pre- and
post-tDCS and changes in recorded ERPs before, during and after tDCS in order to quantify the
response to tDCS over the motor cortex. If EEG metrics can be used to gauge efficacy in
real-time during tDCS administration, the investigators will gain significant insight into
how to appropriately and quantitatively individualize tDCS dosage parameters for each
patient.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06052553 -
A Study of TopSpin360 Training Device
|
N/A | |
| Completed |
NCT05511077 -
Biomarkers of Oat Product Intake: The BiOAT Marker Study
|
N/A | |
| Recruiting |
NCT04632485 -
Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging
|
||
| Completed |
NCT05931237 -
Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults
|
N/A | |
| Terminated |
NCT04556032 -
Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women
|
N/A | |
| Completed |
NCT04527718 -
Study of the Safety, Tolerability and Pharmacokinetics of 611 in Adult Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT04107441 -
AX-8 Drug Safety, Tolerability and Plasma Levels in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04998695 -
Health Effects of Consuming Olive Pomace Oil
|
N/A | |
| Completed |
NCT04065295 -
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 1356225
|
Phase 1 | |
| Completed |
NCT01442831 -
Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects
|
Phase 1 | |
| Terminated |
NCT05934942 -
A Study in Healthy Women to Test Whether BI 1358894 Influences the Amount of a Contraceptive in the Blood
|
Phase 1 | |
| Recruiting |
NCT05525845 -
Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
|
N/A | |
| Completed |
NCT05515328 -
A Study in Healthy Men to Test How BI 685509 is Processed in the Body
|
Phase 1 | |
| Completed |
NCT04967157 -
Cognitive Effects of Citicoline on Attention in Healthy Men and Women
|
N/A | |
| Completed |
NCT05030857 -
Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects
|
Phase 1 | |
| Recruiting |
NCT04494269 -
A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls
|
Phase 1 | |
| Recruiting |
NCT04714294 -
Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT04539756 -
Writing Activities and Emotions
|
N/A | |
| Recruiting |
NCT04098510 -
Concentration of MitoQ in Human Skeletal Muscle
|
N/A | |
| Completed |
NCT03308110 -
Bioavailability and Food Effect Study of Two Formulations of PF-06650833
|
Phase 1 |