Healthy Clinical Trial
Official title:
Absorption, Metabolism and Excretion of Apigenin and Apigenin Glycosides
Probe dietary intervention study in healthy young adult males to evaluate the concentration of apigenin derived metabolites in plasma and urine after single acute intakes of different apigenin-containing test materials.
Flavonoids, including the sub groups of Flavones (FO) are plant-derived compounds commonly
present in the human diet. Examples of FO-containing foods and beverages are parsley, celery,
and chamomile. The study described below will provide initial information of apigenin derived
metabolites in humans. The investigators suggest the information that will be obtained from
the outlined work will be particularly timely given increasing interest in the putative
health effects of FO intake in humans.
This study consisted of two parts. The first part consisted of a probe study in which the
investigators investigated the absorption and metabolism from four flavone-containing test
products. The second phase investigated absorption and metabolism after the intake of a
flavone-containing parsley drink.
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