Effect of Exercise on Muscle Proteome Signature

Healthy Clinical Trial

Official title:

Effect of Exercise Training on Skeletal Muscle Proteome Signature of Young Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03270475
• Other study ID #: ACE
• Status: Completed
• Phase: N/A
• Start date: August 28, 2017
• Est. completion date: October 15, 2017

Study information

• Verified date: January 2021
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

Description:

Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: October 15, 2017
• Est. primary completion date: October 15, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy

• VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)

• Body mass index (BMI) of 19-26 kg/m2

• Normal ECG (electrocardiography)

Exclusion Criteria:

• Serious adverse effects to exercise

• Chronic disease

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• exercise training
subjects complete 4-5 weeks of training

Locations

Country	Name	City	State
Denmark	Department of Nutrition, Exercise and Sports	Copenhagen

Sponsors (1)

Lead Sponsor	Collaborator
Morten Hostrup, PhD

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Skeletal muscle acetylome signature	acetylomics	Change from baseline acetylome signature at 5 weeks
Other	Skeletal muscle mitochondrial respiration	Mitochondrial respiratory capacity	Change from baseline at 5 weeks
Other	Maximal oxygen uptake	Maximal oxygen uptake	Change from baseline at 5 weeks
Primary	Skeletal muscle proteome signature	proteomics	Change from baseline proteome signature at 5 weeks