Cognitive Control of Language

Healthy Clinical Trial

— LANGUAGE  

Official title:

Cognitive Control of Language and Frontal Cortex

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03124173
• Other study ID #: 69HCL16_0684
• Status: Completed
• Phase: N/A
• First received: March 9, 2017
• Last updated: January 17, 2018
• Start date: January 14, 2015
• Est. completion date: May 19, 2016

Study information

• Verified date: January 2018
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The cognitive control of speech is central to human social communication. Two frontal brain regions seem to have a critical role: 1) Broca's area (BA) and 2) the mid-cingulate cortex (MCC). Current rehabilitation strategy is clearly based on therapies promoting language performance. However, there is few evidence that rehabilitation strategies based on nonlinguistic aspects of brain function may enhance recovery. Such strategies may benefit from knowledge about the primary -nonlinguistic- function of the BA-MCC network. The aim of LANGUAGE is to identify this primary function. One hypothesis is that, in non-speaking primates, this network is involved in cognitive control of voluntary vocal/orofacial production. Specifically, whereas BA may be responsible for the high-level selection of orofacial and vocal responses during learning, the face motor representation within the MCC may be responsible for performance monitoring, a process inherently required in learning. LANGUAGE aims to test this hypothesis by determining in human the anatomo-functional organization of the BA-MCC network thanks to functional magnetic resonance imaging (fMRI).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 23
• Est. completion date: May 19, 2016
• Est. primary completion date: May 19, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

• being able to provide a written consent form

• having a social insurance

• have a normal vision (with or without corrections)

• Right-handed

Exclusion Criteria:

• Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc…).

• Subjects must be willing to be advise in case of discovery of brain abnormality.

• History of known neurological or psychiatric illness

• Pregnant or nursing women

• Persons under guardianship, curators or any other administrative or judicial measure of deprivation of rights

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Training session
The subjects will be trained to realize several versions of a learning task of conditional visuo-motor associations.
• First fMRI session
In this session (involving a condition specific to man and a condition that we are certain to obtain in the monkey), subjects will have to learn by trial and error during successive trials, the conditional associations between three abstract stimuli and three Manual responses (3 MRI-compatible mouse buttons).
• Second fMRI session
In this session (involving a condition specific to man and a condition that we are almost certain to obtain in monkeys), subjects will have to learn by trial and error during successive trials, the conditional associations between three abstract stimuli and Three orofacial responses (3 movements of the mouth).
• Third session of fMRI
In this session (involving a human-specific condition and a condition we hope to achieve in the monkey), subjects will have to learn by trial-error in successive trials, conditional associations between three abstract stimuli and three verbal or Vocals.

Locations

Country	Name	City	State
France	Hôpital Henri Mondor	Creteil

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

References & Publications (1)

Hillis AE. Magnetic resonance perfusion imaging in the study of language. Brain Lang. 2007 Aug;102(2):165-75. Epub 2006 Jun 6. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Behavioral data: performance in the task	Performance in the task will be assessed. If performance in the task is <80%, subjects will be excluded in the final analysis	3 years
Primary	fMRI data	BOLD signal will be analyzed in relation to the events of the task. Images must be not too much distorted to allow data analysis. As such, if a subject moved too much (translation>10mm; rotation>5°) the corresponding data will be excluded from the analysis.	3 years