Altruistic Decisions

Healthy Clinical Trial

Official title:

Study on the Parameters That Influence Perceptual Decisions

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03116581
• Other study ID #: 69HCL16_0680
• Status: Terminated
• Phase: N/A
• First received: March 7, 2017
• Last updated: November 24, 2017
• Start date: February 3, 2014
• Est. completion date: July 22, 2016

Study information

• Verified date: November 2017
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study aimed to understand how payoffs for others influence perceptual decision making. The research consists in testing how varying monetary payoffs for another modify the perceptual decision making processes. The use of drift diffusion models on a random dots task enable the characterization of the decision parameter(s) that are modulated when a decision is made to win payoffs for others as compared to decisions for self-benefits. Once the parameter revealed through behavioral experiment, neuroimaging is applied to find the neural correlates of the effects of taking others into account in the decision making process.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 159
• Est. completion date: July 22, 2016
• Est. primary completion date: July 22, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Aged between 18 and 35

• Right-handed

• French

• Normal vision or corrected by contact lenses

Exclusion Criteria:

• Contraindications to the MEG examination

• Presence of a perceptual disorder (vision) or motor impairing the capacity to carry out the tasks requested (including dyschromatopsia and achromatopsia).

• Taking of medical treatment in progress (excluding contraceptive pill).

• Known neurological or psychiatric history or disorders.

• Participants in an exclusion period for any other research.

• Participants who do not benefit from social protection.

• Participants refusing to be informed of the results of the medical examination.

• Participants who refuse to be informed of the possible detection of an anomaly.

• Participants with MRI contraindications

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Behavior
Random-dots tasks: dots appear and move, most have a random trajectory but a given proportion of them move coherently to the same direction. Vicarious reward Each trial begins with a cue, showing 'me' or 'him' and filled rectangle filled proportionally to the payoff. The cue and the square are depicted in yellow (oneself) or blue (other), depending on the beneficiary. The moving dots are then presented and the subjects respond. At the end of dots motion, the feedback is presented. If the response was correct, a pile of coins proportional to the payoff is shown. For incorrect responses and misses, a red-colored cross is displayed. Audience effect Each trial begins with the display of two eyes (public) or a padlock (private). The moving dots are shown and the participant answers. Audience condition changes the information available on accuracy when submitting comments. In the observed condition, an arrow shows the response. In the observed condition, no feedback is displayed.
• fMRI (functional Magnetic Resonance Imagery)
Both behavioral task (audience effect and vicarious reward) will be studied in fMRI (functional Magnetic Resonance Imagery). The same paradigms used in the behavioral experiment will be adapted for fMRI. Audience Effect experiment: trials will last for 10 seconds maximum. With 80 trials for each condition (public easy, public difficult, private easy and private difficult), the task will count a total of 320 trials and have a 54 minutes duration, in 3 runs of 17 minutes each. Vicarious Reward experiment: trials will have a 10 seconds maximum duration. Using 40 trials for each condition (other low payoff, other high payoff, self low payoff, self high payoff, control condition), the task will have a total of 200 trials and last for 54 minutes, in 6 runs of 9 minutes each.
• MEG (MagnetoEncephaloGraphy)
Both behavioral task (audience effect and vicarious reward) will be studied in MEG (MagnetoEncephaloGraphy). The same paradigms used in the behavioral experiment will be used in MEG. Audience Effect experiment: trials will last for 7 seconds maximum. With 100 trials for each condition (public easy, public difficult, private easy and private difficult), the task will count a total of 400 trials and have a 47 minutes duration. Every 100 trials (about 12 minutes of tasks), a break will be proposed to the participants. Vicarious Reward experiment: trials will have a 7.2 seconds maximum duration. Using 75 trials for each condition (other low payoff, other high payoff, self low payoff, self high payoff, control condition), the task will have a total of 375 trials and last for 45 minutes. Every 125 trials (every 15 minutes), a break will be proposed to the participants.

Locations

Country	Name	City	State
France	CH le Vinatier	Bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Modulation of the decisional parameter by the payoff conditions	behavioral data (reaction-times and accuracy) are collected and the decision parameter can be estimated from them using Drift Diffusion Models	1 hour
Primary	Modulation of the decisional parameter by the beneficiary conditions	behavioral data (reaction-times and accuracy) are collected and the decision parameter can be estimated from them using Drift Diffusion Models	1 hour
Secondary	Event-Related potentials	study of the time-locked brain activity	1 hour
Secondary	Time-frequency brain responses	study of the oscillatory activity elicited in the brain	1 hour
Secondary	BOLD	Variation of the blood-oxygen-level dependent (BOLD) signal	1 hour