Healthy Clinical Trial
Official title:
Circadian System Heritability Assessed in Free Living Conditions in a Twin Mediterranean Population
The purpose of this investigation is to assess the role of the genetic and environmental factor on circadian system, in free living conditions by the use of a female twin population. With the results from this study, the investigators expect to advance in the understanding of the role of the endogenicity of the circadian system variables such as temperature, activity, sleep and timing of food intake as the main cause of the coincidence of the rhythms. However, the investigators expected that some parameters are still dependent on environment to a relevant extent and, hence, amenable to change through external interventions.
Twin studies are a classic in the analysis of the relative contribution of genetic and
environmental factors to behavior and other phenotypes. These models are most often used to
separate genetic from environmental causes in the family resemblance methodology. These
models based on twins have been previously carried out in chronobiology. In fact, during the
years 1993 and 1994, Paul Linkowski et al., performed two relevant studies on the circadian
system to analyze the relative contributions of hereditary and/or environmental factors of
cortisol secretion and blood pressure, respectively, and concluded that genetic factors
control some of the characteristics of cortisol and diastolic blood pressure circadian
rhythmicity. The heritability of other circadian markers has also demonstrated such as
morningness- eveningness (44%), sleep-related variables have also pointed to a relevant role
of genetics with heritability estimates of sleep duration between 17% and 55%. However, to
the investigators knowledge, the heritability of other relevant chronobiological markers,
measured in free living conditions such as body temperature, actigraphy and sleep has not
been studied.
These goals will be achieved through a specific approach:
- Observational (Aim 1): To study the potential effect of the genetic and environmental
factor in the circadian system health in order to improve the chronobiological
therapies in the clinical practice (n=106).
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