Healthy Clinical Trial
Official title:
Effects of Native Whey and Milk Supplementation on Changes in Muscle Mass and Strength After 12 Weeks of Strength Training in Young and Elderly
The aim of this study is to investigate the long term adaptations to 11 (elderly) or 12 (young) weeks of strength training when supplemented with native whey or milk. The investigators hypothesize that native whey will give greater increases in muscle hypertrophy and strength than milk.
Increasing or maintaining muscle mass is of great importance for populations ranging from
athletes to patients and elderly. Resistance exercise and protein ingestion are two of the
most potent stimulators of muscle protein synthesis. Both the physical characteristic of
proteins (e.g. different digestion rates of whey and casein) and the amino acid composition,
affects the potential of a certain protein to stimulate muscle protein synthesis. Given its
superior ability to rapidly increase blood leucine concentrations to high levels, whey is
often considered the most potent protein source to stimulate muscle protein synthesis.
Native whey protein is produced by filtration of unprocessed milk. Consequently, native whey
has different characteristics than milk. Of special interest is the higher amounts of the
highly anabolic amino acid leucine in native whey.
The higher levels of leucine can be of great interest for elderly individuals as some
studies in elderly has shown an anabolic resistance to the effects of protein feeding and
strength training. By increasing levels of leucine one might overcome this anabolic
resistance in the elderly.
The aim of this double-blinded, randomized, partial cross-over study is to compare the
changes in muscle hypertrophy and strength after a 11 (elderly) or 12 (young) week training
intervention with daily supplementation of either 2x20g of native whey or milk proteins in
young and elderly individuals. In order to explain potential differences between supplements
an acute study investigating acute responses in blood amino acid concentrations and
intracellular signalling is planned, in a subgroup of participants, before and after the
training intervention.
The investigators hypothesize that native whey will induce greater muscle hypertrophy and
strength gains than milk.
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