Normal Brain Imaging Database for Brain Disorder Studies

Healthy Clinical Trial

— Normal_tDCS  

Official title:

Normal Brain Imaging Database for Brain Disorder Studies

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03027869
• Other study ID #: B2016:074
• Status: Active, not recruiting
• Phase: N/A
• Start date: June 28, 2017
• Est. completion date: December 31, 2023

Study information

• Verified date: May 2023
• Source: University of Manitoba
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Healthy volunteers will be recruited. All subjects will be tested a battery of neuropsychological tests, then undergo fluorodeoxyglucose-positron emission tomography (PET) and magnetic resonance imaging (MRI). During the PET and MRI, they will be stimulated with transcranial direct current stimulation (tDCS) for 15 minutes. A third of subjects will receive real tDCS on the left prefrontal cortex, a third on the right prefrontal cortex, and the other third will receive sham tDCS.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 40
• Est. completion date: December 31, 2023
• Est. primary completion date: March 11, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• N/A

Exclusion Criteria:

• History of any neurological or psychiatric diseases;

• Abnormal MRI;

• metal implants or a cardiac pacemaker;

• Pregnant or breastfeeding women (female subjects of child bearing potential will be screened for pregnancy before MRI imaging).

• severe hypertension.

• cardiovascular disease.

• Family history of epilepsy.

Related Conditions & MeSH terms

• Brain Diseases
• Healthy

Intervention

Device:
• transcranial direct current stimulation
15 minute anodal stimulation 1.5mA

Locations

Country	Name	City	State
Canada	University of Manitoba	Winnipeg	Manitoba

Sponsors (1)

Lead Sponsor	Collaborator
University of Manitoba

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	functional connectivity	The functional connectivity of the right caudate nucleus will be estimated using graph theory analysis technique of resting-state fMRI.	immediate (less than 30 minutes)
Secondary	Stroop task performance	the executive function that is thought to involve the caudate nucleus will be examined	immediate (less than 60 minutes)