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A Study of Oral Hymecromone and Hyaluronan Synthesis

Healthy Clinical Trial

Official title:
Dose Ranging Studies of Oral Hymecromone on Hyaluronan Synthesis

Clinical Trial Summary

The purpose of this study is to add further understanding to the doses of hymecromone that effectively and safely lead to the inhibition of hyaluronan synthesis. In this study we will investigate both circulating hyaluronan in the serum, as well as tissue hyaluronan, using sputum samples as a non-invasive surrogate. This is a parallel, open-label, single-center, dose-response study of hymecromone in healthy adults 18 years of age or older. Up to 18 participants will be enrolled. Participants will be treated for 4 days with study drug. Safety as well as biomarkers of pharmacokinetic and pharmacodynamic response will be monitored during therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02780752
Study type Interventional
Source Stanford University
Contact
Status Completed
Phase Phase 1
Start date December 1, 2020
Completion date May 10, 2021
View Details
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